PBS Kids continued to air reruns of the 2000 series until 2022.

On May 16, 2018, Scholastic announced a reboot of the series of the same name, which was released on December 6, 2019, on Amazon Prime Video and December 7, 2019, on PBS Kids, starring Adam Sanders as the new voice of Clifford. Clifford's Really Big Movie served as the series finale, Clifford's Puppy Days still continued to air until its cancellation in 2006. Though production of Clifford ended before Ritter's death, voice actors for the main characters have reprised some of their roles for the Ready to Learn PBS Kids PSAs. Ritter's death on September 11, 2003, came less than two weeks before the debut of Clifford's Puppy Days (it is often mistakenly cited as the reason the spin-off was created in lieu of a third season). By the time the series ended production and the subsequent film Clifford's Really Big Movie were completed, Ritter was back on ABC's prime time schedule, starring in 8 Simple Rules. John Ritter voices Clifford in every episode. Internationally, German-based TV-Loonland AG handled broadcast rights to the series, while Entertainment Rights held merchandising and home media rights.

A UK version (dubbed with British voice actors replacing the original American soundtrack) originally aired on BBC Two in April 2002. Produced by Scholastic Productions, it originally aired on PBS Kids from September 4, 2000, to February 25, 2003. Clifford the Big Red Dog is an American/British animated educational children's television series, based upon Norman Bridwell's children's book series of the same name.

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